<?xml version="1.0" encoding="UTF-8"?>
<document filename='bm_us-015-str.xml'>
   <table id='1'>
      <region id='1' col-increment='0' row-increment='0' page='2'>
         <cell id='1' start-row='0' start-col='0' >
            <bounding-box x1='116' y1='467' x2='189' y2='479'/>
            <content>Item Property</content>
            <instruction instr-id='156' subinstr-id='0'/>
         </cell>
         <cell id='1' start-row='0' start-col='1' >
            <bounding-box x1='294' y1='467' x2='452' y2='479'/>
            <content>Reason for Change or Deletion</content>
            <instruction instr-id='156' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='1' start-col='0' >
            <bounding-box x1='90' y1='448' x2='177' y2='459'/>
            <content>Clarity or relevance</content>
            <instruction instr-id='178' subinstr-id='0'/>
            <instruction instr-id='178' subinstr-id='2'/>
            <instruction instr-id='178' subinstr-id='4'/>
            <instruction instr-id='178' subinstr-id='6'/>
         </cell>
         <cell id='1' start-row='2' start-col='0' >
            <bounding-box x1='90' y1='367' x2='159' y2='378'/>
            <content>Response range</content>
            <instruction instr-id='273' subinstr-id='0'/>
            <instruction instr-id='273' subinstr-id='2'/>
            <instruction instr-id='273' subinstr-id='4'/>
         </cell>
         <cell id='1' start-row='3' start-col='0' >
            <bounding-box x1='90' y1='308' x2='137' y2='319'/>
            <content>Variability</content>
            <instruction instr-id='347' subinstr-id='0'/>
         </cell>
         <cell id='1' start-row='4' start-col='0' >
            <bounding-box x1='90' y1='255' x2='159' y2='266'/>
            <content>Reproducibility</content>
            <instruction instr-id='414' subinstr-id='0'/>
            <instruction instr-id='414' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='5' start-col='0' >
            <bounding-box x1='90' y1='230' x2='184' y2='241'/>
            <content>Inter-item correlation</content>
            <instruction instr-id='452' subinstr-id='0'/>
            <instruction instr-id='452' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='6' start-col='0' >
            <bounding-box x1='90' y1='205' x2='196' y2='216'/>
            <content>Ability to detect change</content>
            <instruction instr-id='491' subinstr-id='0'/>
            <instruction instr-id='491' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='7' start-col='0' >
            <bounding-box x1='90' y1='181' x2='176' y2='192'/>
            <content>Item discrimination</content>
            <instruction instr-id='530' subinstr-id='0'/>
            <instruction instr-id='530' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='8' start-col='0' >
            <bounding-box x1='90' y1='121' x2='144' y2='132'/>
            <content>Redundancy</content>
            <instruction instr-id='602' subinstr-id='0'/>
            <instruction instr-id='602' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='9' start-col='0' >
            <bounding-box x1='90' y1='96' x2='148' y2='107'/>
            <content>Recall period</content>
            <instruction instr-id='645' subinstr-id='-1'/>
         </cell>
         <cell id='1' start-row='1' start-col='1' >
            <bounding-box x1='225' y1='384' x2='515' y2='458'/>
            <content>• Reported as not relevant by a large segment of the target population
• Generates an unacceptably large amount of missing data points
• Generates many questions or requests for clarification from patients as they
complete the PRO instrument
• Patients interpret items and responses in a way that is inconsistent with the
PRO instrument’s conceptual framework</content>
            <instruction instr-id='182' subinstr-id='-1'/>
            <instruction instr-id='191' subinstr-id='0'/>
            <instruction instr-id='191' subinstr-id='2'/>
            <instruction instr-id='191' subinstr-id='4'/>
            <instruction instr-id='191' subinstr-id='6'/>
            <instruction instr-id='191' subinstr-id='8'/>
            <instruction instr-id='191' subinstr-id='10'/>
            <instruction instr-id='191' subinstr-id='12'/>
            <instruction instr-id='191' subinstr-id='16'/>
            <instruction instr-id='191' subinstr-id='18'/>
            <instruction instr-id='195' subinstr-id='0'/>
            <instruction instr-id='195' subinstr-id='2'/>
            <instruction instr-id='199' subinstr-id='-1'/>
            <instruction instr-id='208' subinstr-id='0'/>
            <instruction instr-id='208' subinstr-id='2'/>
            <instruction instr-id='208' subinstr-id='4'/>
            <instruction instr-id='208' subinstr-id='6'/>
            <instruction instr-id='208' subinstr-id='8'/>
            <instruction instr-id='208' subinstr-id='12'/>
            <instruction instr-id='208' subinstr-id='14'/>
            <instruction instr-id='212' subinstr-id='0'/>
            <instruction instr-id='212' subinstr-id='2'/>
            <instruction instr-id='216' subinstr-id='-1'/>
            <instruction instr-id='225' subinstr-id='0'/>
            <instruction instr-id='225' subinstr-id='2'/>
            <instruction instr-id='225' subinstr-id='6'/>
            <instruction instr-id='225' subinstr-id='8'/>
            <instruction instr-id='225' subinstr-id='10'/>
            <instruction instr-id='225' subinstr-id='12'/>
            <instruction instr-id='229' subinstr-id='0'/>
            <instruction instr-id='229' subinstr-id='2'/>
            <instruction instr-id='229' subinstr-id='4'/>
            <instruction instr-id='229' subinstr-id='6'/>
            <instruction instr-id='229' subinstr-id='8'/>
            <instruction instr-id='229' subinstr-id='10'/>
            <instruction instr-id='229' subinstr-id='12'/>
            <instruction instr-id='229' subinstr-id='14'/>
            <instruction instr-id='229' subinstr-id='16'/>
            <instruction instr-id='229' subinstr-id='18'/>
            <instruction instr-id='229' subinstr-id='20'/>
            <instruction instr-id='229' subinstr-id='22'/>
            <instruction instr-id='233' subinstr-id='0'/>
            <instruction instr-id='233' subinstr-id='2'/>
            <instruction instr-id='233' subinstr-id='4'/>
            <instruction instr-id='233' subinstr-id='6'/>
            <instruction instr-id='233' subinstr-id='8'/>
            <instruction instr-id='233' subinstr-id='10'/>
            <instruction instr-id='233' subinstr-id='12'/>
            <instruction instr-id='233' subinstr-id='14'/>
            <instruction instr-id='237' subinstr-id='-1'/>
            <instruction instr-id='246' subinstr-id='0'/>
            <instruction instr-id='246' subinstr-id='2'/>
            <instruction instr-id='246' subinstr-id='4'/>
            <instruction instr-id='246' subinstr-id='6'/>
            <instruction instr-id='246' subinstr-id='8'/>
            <instruction instr-id='246' subinstr-id='10'/>
            <instruction instr-id='246' subinstr-id='12'/>
            <instruction instr-id='246' subinstr-id='14'/>
            <instruction instr-id='246' subinstr-id='16'/>
            <instruction instr-id='246' subinstr-id='18'/>
            <instruction instr-id='246' subinstr-id='20'/>
            <instruction instr-id='246' subinstr-id='22'/>
            <instruction instr-id='246' subinstr-id='24'/>
            <instruction instr-id='246' subinstr-id='26'/>
            <instruction instr-id='246' subinstr-id='28'/>
            <instruction instr-id='246' subinstr-id='30'/>
            <instruction instr-id='246' subinstr-id='32'/>
            <instruction instr-id='246' subinstr-id='34'/>
            <instruction instr-id='250' subinstr-id='0'/>
            <instruction instr-id='250' subinstr-id='2'/>
            <instruction instr-id='250' subinstr-id='4'/>
            <instruction instr-id='250' subinstr-id='6'/>
            <instruction instr-id='250' subinstr-id='8'/>
            <instruction instr-id='250' subinstr-id='10'/>
            <instruction instr-id='250' subinstr-id='12'/>
            <instruction instr-id='250' subinstr-id='14'/>
            <instruction instr-id='250' subinstr-id='16'/>
            <instruction instr-id='250' subinstr-id='18'/>
            <instruction instr-id='250' subinstr-id='20'/>
            <instruction instr-id='250' subinstr-id='22'/>
            <instruction instr-id='250' subinstr-id='24'/>
         </cell>
         <cell id='1' start-row='2' start-col='1' >
            <bounding-box x1='225' y1='327' x2='513' y2='377'/>
            <content>• A high percent of patients respond at the floor (response scale’s worst end)
or ceiling (response scale’s optimal end)
• Patients note that none of the response choices applies to them
• Distribution of item responses is highly skewed</content>
            <instruction instr-id='277' subinstr-id='-1'/>
            <instruction instr-id='286' subinstr-id='0'/>
            <instruction instr-id='286' subinstr-id='2'/>
            <instruction instr-id='286' subinstr-id='4'/>
            <instruction instr-id='286' subinstr-id='6'/>
            <instruction instr-id='286' subinstr-id='8'/>
            <instruction instr-id='286' subinstr-id='10'/>
            <instruction instr-id='286' subinstr-id='12'/>
            <instruction instr-id='290' subinstr-id='0'/>
            <instruction instr-id='290' subinstr-id='2'/>
            <instruction instr-id='290' subinstr-id='4'/>
            <instruction instr-id='290' subinstr-id='6'/>
            <instruction instr-id='294' subinstr-id='0'/>
            <instruction instr-id='294' subinstr-id='2'/>
            <instruction instr-id='294' subinstr-id='4'/>
            <instruction instr-id='298' subinstr-id='-1'/>
            <instruction instr-id='307' subinstr-id='0'/>
            <instruction instr-id='307' subinstr-id='2'/>
            <instruction instr-id='307' subinstr-id='4'/>
            <instruction instr-id='307' subinstr-id='6'/>
            <instruction instr-id='311' subinstr-id='0'/>
            <instruction instr-id='311' subinstr-id='2'/>
            <instruction instr-id='311' subinstr-id='4'/>
            <instruction instr-id='311' subinstr-id='6'/>
            <instruction instr-id='311' subinstr-id='8'/>
            <instruction instr-id='311' subinstr-id='10'/>
            <instruction instr-id='315' subinstr-id='-1'/>
            <instruction instr-id='324' subinstr-id='0'/>
            <instruction instr-id='324' subinstr-id='2'/>
            <instruction instr-id='324' subinstr-id='4'/>
            <instruction instr-id='324' subinstr-id='6'/>
         </cell>
         <cell id='1' start-row='3' start-col='1' >
            <bounding-box x1='225' y1='268' x2='516' y2='318'/>
            <content>• All patients give the same answer (i.e., no variance)
• Most patients choose only one response choice
• Differences among patients are not detected when important differences are
known</content>
            <instruction instr-id='351' subinstr-id='-1'/>
            <instruction instr-id='360' subinstr-id='0'/>
            <instruction instr-id='360' subinstr-id='2'/>
            <instruction instr-id='360' subinstr-id='4'/>
            <instruction instr-id='360' subinstr-id='6'/>
            <instruction instr-id='360' subinstr-id='8'/>
            <instruction instr-id='360' subinstr-id='10'/>
            <instruction instr-id='360' subinstr-id='12'/>
            <instruction instr-id='360' subinstr-id='14'/>
            <instruction instr-id='360' subinstr-id='16'/>
            <instruction instr-id='364' subinstr-id='-1'/>
            <instruction instr-id='373' subinstr-id='0'/>
            <instruction instr-id='373' subinstr-id='2'/>
            <instruction instr-id='373' subinstr-id='4'/>
            <instruction instr-id='373' subinstr-id='6'/>
            <instruction instr-id='373' subinstr-id='8'/>
            <instruction instr-id='373' subinstr-id='10'/>
            <instruction instr-id='373' subinstr-id='12'/>
            <instruction instr-id='377' subinstr-id='-1'/>
            <instruction instr-id='386' subinstr-id='0'/>
            <instruction instr-id='386' subinstr-id='2'/>
            <instruction instr-id='386' subinstr-id='4'/>
            <instruction instr-id='386' subinstr-id='6'/>
            <instruction instr-id='386' subinstr-id='8'/>
            <instruction instr-id='386' subinstr-id='10'/>
            <instruction instr-id='386' subinstr-id='12'/>
            <instruction instr-id='386' subinstr-id='16'/>
            <instruction instr-id='386' subinstr-id='18'/>
            <instruction instr-id='386' subinstr-id='20'/>
            <instruction instr-id='386' subinstr-id='22'/>
            <instruction instr-id='386' subinstr-id='24'/>
            <instruction instr-id='386' subinstr-id='26'/>
            <instruction instr-id='386' subinstr-id='28'/>
            <instruction instr-id='386' subinstr-id='30'/>
            <instruction instr-id='386' subinstr-id='32'/>
            <instruction instr-id='386' subinstr-id='34'/>
            <instruction instr-id='386' subinstr-id='36'/>
            <instruction instr-id='386' subinstr-id='38'/>
            <instruction instr-id='386' subinstr-id='40'/>
            <instruction instr-id='386' subinstr-id='44'/>
            <instruction instr-id='392' subinstr-id='-1'/>
         </cell>
         <cell id='1' start-row='4' start-col='1' >
            <bounding-box x1='225' y1='243' x2='517' y2='265'/>
            <content>• Unstable scores over time when there is no logical reason for variation from
one assessment to the next</content>
            <instruction instr-id='418' subinstr-id='-1'/>
            <instruction instr-id='426' subinstr-id='0'/>
            <instruction instr-id='426' subinstr-id='2'/>
            <instruction instr-id='426' subinstr-id='4'/>
            <instruction instr-id='426' subinstr-id='6'/>
            <instruction instr-id='426' subinstr-id='8'/>
            <instruction instr-id='426' subinstr-id='10'/>
            <instruction instr-id='426' subinstr-id='14'/>
            <instruction instr-id='426' subinstr-id='16'/>
            <instruction instr-id='426' subinstr-id='18'/>
            <instruction instr-id='426' subinstr-id='20'/>
            <instruction instr-id='426' subinstr-id='22'/>
            <instruction instr-id='426' subinstr-id='24'/>
            <instruction instr-id='426' subinstr-id='26'/>
            <instruction instr-id='426' subinstr-id='28'/>
            <instruction instr-id='430' subinstr-id='0'/>
            <instruction instr-id='430' subinstr-id='2'/>
            <instruction instr-id='430' subinstr-id='4'/>
            <instruction instr-id='430' subinstr-id='6'/>
            <instruction instr-id='434' subinstr-id='0'/>
            <instruction instr-id='434' subinstr-id='2'/>
            <instruction instr-id='434' subinstr-id='4'/>
            <instruction instr-id='434' subinstr-id='6'/>
            <instruction instr-id='434' subinstr-id='8'/>
            <instruction instr-id='434' subinstr-id='10'/>
            <instruction instr-id='434' subinstr-id='12'/>
         </cell>
         <cell id='1' start-row='5' start-col='1' >
            <bounding-box x1='225' y1='218' x2='512' y2='241'/>
            <content>• Item highly correlated (redundant) withother items in the same concept of
interest</content>
            <instruction instr-id='456' subinstr-id='-1'/>
            <instruction instr-id='465' subinstr-id='0'/>
            <instruction instr-id='465' subinstr-id='4'/>
            <instruction instr-id='465' subinstr-id='6'/>
            <instruction instr-id='465' subinstr-id='8'/>
            <instruction instr-id='465' subinstr-id='10'/>
            <instruction instr-id='465' subinstr-id='12'/>
            <instruction instr-id='465' subinstr-id='14'/>
            <instruction instr-id='469' subinstr-id='-1'/>
            <instruction instr-id='473' subinstr-id='0'/>
            <instruction instr-id='473' subinstr-id='2'/>
            <instruction instr-id='473' subinstr-id='4'/>
         </cell>
         <cell id='1' start-row='6' start-col='1' >
            <bounding-box x1='225' y1='193' x2='515' y2='216'/>
            <content>• Item is not sensitive (i.e., does not change when there is a known change in
the concepts of interest)</content>
            <instruction instr-id='495' subinstr-id='-1'/>
            <instruction instr-id='504' subinstr-id='0'/>
            <instruction instr-id='504' subinstr-id='2'/>
            <instruction instr-id='504' subinstr-id='4'/>
            <instruction instr-id='508' subinstr-id='0'/>
            <instruction instr-id='508' subinstr-id='2'/>
            <instruction instr-id='508' subinstr-id='4'/>
            <instruction instr-id='508' subinstr-id='6'/>
            <instruction instr-id='508' subinstr-id='8'/>
            <instruction instr-id='508' subinstr-id='10'/>
            <instruction instr-id='508' subinstr-id='12'/>
            <instruction instr-id='508' subinstr-id='14'/>
            <instruction instr-id='512' subinstr-id='0'/>
            <instruction instr-id='512' subinstr-id='2'/>
            <instruction instr-id='512' subinstr-id='4'/>
            <instruction instr-id='512' subinstr-id='6'/>
            <instruction instr-id='512' subinstr-id='8'/>
            <instruction instr-id='512' subinstr-id='10'/>
         </cell>
         <cell id='1' start-row='7' start-col='1' >
            <bounding-box x1='225' y1='134' x2='521' y2='191'/>
            <content>• Item is highly correlated with measures of concepts other than the one it is
intended to measure
• Item does not show variability in relation to some known population
characteristics (i.e., severity level, classification of condition, or other known
characteristic)</content>
            <instruction instr-id='534' subinstr-id='-1'/>
            <instruction instr-id='543' subinstr-id='0'/>
            <instruction instr-id='543' subinstr-id='2'/>
            <instruction instr-id='543' subinstr-id='4'/>
            <instruction instr-id='543' subinstr-id='6'/>
            <instruction instr-id='543' subinstr-id='10'/>
            <instruction instr-id='543' subinstr-id='12'/>
            <instruction instr-id='543' subinstr-id='14'/>
            <instruction instr-id='543' subinstr-id='16'/>
            <instruction instr-id='543' subinstr-id='18'/>
            <instruction instr-id='543' subinstr-id='20'/>
            <instruction instr-id='547' subinstr-id='0'/>
            <instruction instr-id='547' subinstr-id='2'/>
            <instruction instr-id='547' subinstr-id='4'/>
            <instruction instr-id='547' subinstr-id='6'/>
            <instruction instr-id='547' subinstr-id='8'/>
            <instruction instr-id='547' subinstr-id='10'/>
            <instruction instr-id='547' subinstr-id='12'/>
            <instruction instr-id='551' subinstr-id='0'/>
            <instruction instr-id='551' subinstr-id='2'/>
            <instruction instr-id='551' subinstr-id='4'/>
            <instruction instr-id='551' subinstr-id='6'/>
            <instruction instr-id='551' subinstr-id='8'/>
            <instruction instr-id='555' subinstr-id='-1'/>
            <instruction instr-id='564' subinstr-id='0'/>
            <instruction instr-id='564' subinstr-id='2'/>
            <instruction instr-id='564' subinstr-id='4'/>
            <instruction instr-id='564' subinstr-id='6'/>
            <instruction instr-id='564' subinstr-id='10'/>
            <instruction instr-id='568' subinstr-id='0'/>
            <instruction instr-id='568' subinstr-id='2'/>
            <instruction instr-id='568' subinstr-id='4'/>
            <instruction instr-id='572' subinstr-id='-1'/>
            <instruction instr-id='576' subinstr-id='0'/>
            <instruction instr-id='576' subinstr-id='2'/>
            <instruction instr-id='576' subinstr-id='4'/>
            <instruction instr-id='576' subinstr-id='6'/>
            <instruction instr-id='580' subinstr-id='0'/>
            <instruction instr-id='580' subinstr-id='2'/>
            <instruction instr-id='580' subinstr-id='4'/>
            <instruction instr-id='584' subinstr-id='0'/>
            <instruction instr-id='584' subinstr-id='2'/>
            <instruction instr-id='584' subinstr-id='4'/>
            <instruction instr-id='584' subinstr-id='6'/>
            <instruction instr-id='584' subinstr-id='8'/>
            <instruction instr-id='584' subinstr-id='10'/>
            <instruction instr-id='584' subinstr-id='12'/>
            <instruction instr-id='584' subinstr-id='14'/>
            <instruction instr-id='584' subinstr-id='16'/>
         </cell>
         <cell id='1' start-row='8' start-col='1' >
            <bounding-box x1='225' y1='109' x2='505' y2='131'/>
            <content>• Item duplicates information collected with other items that have equal or
better measurement properties</content>
            <instruction instr-id='606' subinstr-id='-1'/>
            <instruction instr-id='615' subinstr-id='-1'/>
            <instruction instr-id='619' subinstr-id='0'/>
            <instruction instr-id='619' subinstr-id='2'/>
            <instruction instr-id='619' subinstr-id='4'/>
            <instruction instr-id='619' subinstr-id='6'/>
            <instruction instr-id='623' subinstr-id='0'/>
            <instruction instr-id='623' subinstr-id='2'/>
            <instruction instr-id='623' subinstr-id='4'/>
            <instruction instr-id='623' subinstr-id='6'/>
            <instruction instr-id='627' subinstr-id='0'/>
            <instruction instr-id='627' subinstr-id='2'/>
            <instruction instr-id='627' subinstr-id='4'/>
            <instruction instr-id='627' subinstr-id='6'/>
            <instruction instr-id='627' subinstr-id='8'/>
            <instruction instr-id='627' subinstr-id='10'/>
            <instruction instr-id='627' subinstr-id='12'/>
         </cell>
         <cell id='1' start-row='9' start-col='1' >
            <bounding-box x1='225' y1='84' x2='516' y2='106'/>
            <content>• The population, disease state, or application of the instrument can affect the
appropriateness of the recall period</content>
            <instruction instr-id='649' subinstr-id='-1'/>
            <instruction instr-id='658' subinstr-id='0'/>
            <instruction instr-id='658' subinstr-id='2'/>
            <instruction instr-id='658' subinstr-id='4'/>
            <instruction instr-id='658' subinstr-id='6'/>
            <instruction instr-id='661' subinstr-id='0'/>
            <instruction instr-id='661' subinstr-id='2'/>
            <instruction instr-id='661' subinstr-id='4'/>
            <instruction instr-id='661' subinstr-id='6'/>
            <instruction instr-id='665' subinstr-id='0'/>
            <instruction instr-id='665' subinstr-id='2'/>
            <instruction instr-id='665' subinstr-id='4'/>
            <instruction instr-id='665' subinstr-id='6'/>
         </cell>
      </region>
   </table>
   <table id='2'>
      <region id='1' col-increment='0' row-increment='0' page='4'>
         <cell id='1' start-row='0' start-col='0' >
            <bounding-box x1='82' y1='504' x2='141' y2='526'/>
            <content>Measurement
Property</content>
            <instruction instr-id='25' subinstr-id='-1'/>
            <instruction instr-id='28' subinstr-id='0'/>
            <instruction instr-id='28' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='0' start-col='1' >
            <bounding-box x1='211' y1='516' x2='233' y2='526'/>
            <content>Type</content>
            <instruction instr-id='32' subinstr-id='0'/>
         </cell>
         <cell id='1' start-row='0' start-col='2' >
            <bounding-box x1='345' y1='516' x2='424' y2='526'/>
            <content>What Is Assessed?</content>
            <instruction instr-id='32' subinstr-id='2'/>
            <instruction instr-id='32' subinstr-id='4'/>
            <instruction instr-id='32' subinstr-id='6'/>
         </cell>
         <cell id='1' start-row='0' start-col='3' >
            <bounding-box x1='549' y1='516' x2='670' y2='526'/>
            <content>FDA Review Considerations</content>
            <instruction instr-id='32' subinstr-id='8'/>
            <instruction instr-id='32' subinstr-id='10'/>
            <instruction instr-id='32' subinstr-id='12'/>
            <instruction instr-id='32' subinstr-id='14'/>
         </cell>
         <cell id='1' start-row='1' start-col='0'  end-row='3'>
            <bounding-box x1='72' y1='492' x2='114' y2='502'/>
            <content>Reliability</content>
            <instruction instr-id='230' subinstr-id='0'/>
            <instruction instr-id='230' subinstr-id='2'/>
            <instruction instr-id='230' subinstr-id='4'/>
         </cell>
         <cell id='1' start-row='4' start-col='0'  end-row='5'>
            <bounding-box x1='72' y1='327' x2='104' y2='337'/>
            <content>Validity</content>
            <instruction instr-id='451' subinstr-id='0'/>
            <instruction instr-id='451' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='6' start-col='0'>
            <bounding-box x1='72' y1='142' x2='137' y2='163'/>
            <content>Ability to detect
change</content>
            <instruction instr-id='589' subinstr-id='0'/>
            <instruction instr-id='589' subinstr-id='2'/>
            <instruction instr-id='589' subinstr-id='4'/>
            <instruction instr-id='596' subinstr-id='-1'/>
         </cell>
         <cell id='1' start-row='4' start-col='1' >
            <bounding-box x1='162' y1='327' x2='227' y2='337'/>
            <content>Content validity</content>
            <instruction instr-id='298' subinstr-id='0'/>
            <instruction instr-id='298' subinstr-id='2'/>
            <instruction instr-id='298' subinstr-id='4'/>
            <instruction instr-id='298' subinstr-id='6'/>
            <instruction instr-id='298' subinstr-id='8'/>
            <instruction instr-id='298' subinstr-id='10'/>
            <instruction instr-id='298' subinstr-id='12'/>
            <instruction instr-id='298' subinstr-id='14'/>
         </cell>
         <cell id='1' start-row='5' start-col='1' >
            <bounding-box x1='162' y1='223' x2='234' y2='233'/>
            <content>Construct validity</content>
            <instruction instr-id='461' subinstr-id='0'/>
            <instruction instr-id='461' subinstr-id='2'/>
            <instruction instr-id='461' subinstr-id='4'/>
            <instruction instr-id='461' subinstr-id='6'/>
            <instruction instr-id='461' subinstr-id='8'/>
            <instruction instr-id='461' subinstr-id='10'/>
            <instruction instr-id='461' subinstr-id='12'/>
            <instruction instr-id='461' subinstr-id='14'/>
            <instruction instr-id='461' subinstr-id='16'/>
            <instruction instr-id='461' subinstr-id='18'/>
         </cell>
         <cell id='1' start-row='3' start-col='1' >
            <bounding-box x1='162' y1='363' x2='280' y2='396'/>
            <content>Inter-interviewer reliability
(for interviewer-administered
PROs only)</content>
            <instruction instr-id='235' subinstr-id='0'/>
            <instruction instr-id='235' subinstr-id='2'/>
            <instruction instr-id='235' subinstr-id='4'/>
            <instruction instr-id='235' subinstr-id='6'/>
            <instruction instr-id='235' subinstr-id='8'/>
            <instruction instr-id='239' subinstr-id='0'/>
            <instruction instr-id='239' subinstr-id='2'/>
            <instruction instr-id='239' subinstr-id='4'/>
            <instruction instr-id='239' subinstr-id='6'/>
            <instruction instr-id='239' subinstr-id='8'/>
            <instruction instr-id='239' subinstr-id='10'/>
            <instruction instr-id='239' subinstr-id='12'/>
            <instruction instr-id='239' subinstr-id='14'/>
            <instruction instr-id='246' subinstr-id='-1'/>
         </cell>
         <cell id='1' start-row='1' start-col='1' >
            <bounding-box x1='162' y1='458' x2='267' y2='503'/>
            <content>Test-retest or intra-
interviewer reliability (for
interviewer-administered
PROs only)</content>
            <instruction instr-id='58' subinstr-id='0'/>
            <instruction instr-id='58' subinstr-id='2'/>
            <instruction instr-id='58' subinstr-id='4'/>
            <instruction instr-id='58' subinstr-id='6'/>
            <instruction instr-id='64' subinstr-id='0'/>
            <instruction instr-id='64' subinstr-id='2'/>
            <instruction instr-id='64' subinstr-id='4'/>
            <instruction instr-id='64' subinstr-id='6'/>
            <instruction instr-id='64' subinstr-id='8'/>
            <instruction instr-id='70' subinstr-id='0'/>
            <instruction instr-id='70' subinstr-id='2'/>
            <instruction instr-id='70' subinstr-id='4'/>
            <instruction instr-id='70' subinstr-id='6'/>
            <instruction instr-id='70' subinstr-id='8'/>
            <instruction instr-id='76' subinstr-id='-1'/>
         </cell>
         <cell id='1' start-row='2' start-col='1' >
            <bounding-box x1='162' y1='446' x2='243' y2='456'/>
            <content>Internal consistency</content>
            <instruction instr-id='133' subinstr-id='0'/>
            <instruction instr-id='133' subinstr-id='2'/>
            <instruction instr-id='133' subinstr-id='4'/>
            <instruction instr-id='133' subinstr-id='6'/>
            <instruction instr-id='133' subinstr-id='8'/>
            <instruction instr-id='133' subinstr-id='10'/>
         </cell>
         <cell id='1' start-row='1' start-col='2' >
            <bounding-box x1='293' y1='481' x2='473' y2='503'/>
            <content>Stability of scores over time when no change
is expected in the concept of interest</content>
            <instruction instr-id='80' subinstr-id='0'/>
            <instruction instr-id='80' subinstr-id='2'/>
            <instruction instr-id='80' subinstr-id='4'/>
            <instruction instr-id='80' subinstr-id='6'/>
            <instruction instr-id='80' subinstr-id='8'/>
            <instruction instr-id='80' subinstr-id='10'/>
            <instruction instr-id='80' subinstr-id='12'/>
            <instruction instr-id='80' subinstr-id='14'/>
            <instruction instr-id='80' subinstr-id='16'/>
            <instruction instr-id='80' subinstr-id='18'/>
            <instruction instr-id='80' subinstr-id='20'/>
            <instruction instr-id='80' subinstr-id='24'/>
            <instruction instr-id='80' subinstr-id='26'/>
            <instruction instr-id='80' subinstr-id='28'/>
            <instruction instr-id='86' subinstr-id='0'/>
            <instruction instr-id='86' subinstr-id='2'/>
            <instruction instr-id='86' subinstr-id='4'/>
            <instruction instr-id='86' subinstr-id='6'/>
            <instruction instr-id='86' subinstr-id='8'/>
            <instruction instr-id='86' subinstr-id='10'/>
            <instruction instr-id='86' subinstr-id='12'/>
            <instruction instr-id='86' subinstr-id='14'/>
            <instruction instr-id='86' subinstr-id='16'/>
         </cell>
         <cell id='1' start-row='1' start-col='3' >
            <bounding-box x1='486' y1='480' x2='634' y2='502'/>
            <content>• Intraclass correlation coefficient
• Time period of assessment</content>
            <instruction instr-id='90' subinstr-id='-1'/>
            <instruction instr-id='99' subinstr-id='0'/>
            <instruction instr-id='99' subinstr-id='2'/>
            <instruction instr-id='99' subinstr-id='4'/>
            <instruction instr-id='103' subinstr-id='-1'/>
            <instruction instr-id='111' subinstr-id='0'/>
            <instruction instr-id='111' subinstr-id='2'/>
            <instruction instr-id='111' subinstr-id='4'/>
            <instruction instr-id='111' subinstr-id='6'/>
            <instruction instr-id='111' subinstr-id='8'/>
         </cell>
         <cell id='1' start-row='2' start-col='2' >
            <bounding-box x1='293' y1='398' x2='475' y2='455'/>
            <content>• Extent to which items comprising a scale
measure the same concept
• Intercorrelation of items that contribute
to a score
• Internal consistency</content>
            <instruction instr-id='137' subinstr-id='-1'/>
            <instruction instr-id='146' subinstr-id='0'/>
            <instruction instr-id='146' subinstr-id='2'/>
            <instruction instr-id='146' subinstr-id='6'/>
            <instruction instr-id='146' subinstr-id='8'/>
            <instruction instr-id='146' subinstr-id='10'/>
            <instruction instr-id='146' subinstr-id='12'/>
            <instruction instr-id='146' subinstr-id='14'/>
            <instruction instr-id='146' subinstr-id='16'/>
            <instruction instr-id='150' subinstr-id='0'/>
            <instruction instr-id='150' subinstr-id='2'/>
            <instruction instr-id='150' subinstr-id='4'/>
            <instruction instr-id='150' subinstr-id='6'/>
            <instruction instr-id='150' subinstr-id='8'/>
            <instruction instr-id='154' subinstr-id='-1'/>
            <instruction instr-id='163' subinstr-id='0'/>
            <instruction instr-id='163' subinstr-id='2'/>
            <instruction instr-id='163' subinstr-id='6'/>
            <instruction instr-id='163' subinstr-id='8'/>
            <instruction instr-id='163' subinstr-id='10'/>
            <instruction instr-id='163' subinstr-id='12'/>
            <instruction instr-id='163' subinstr-id='14'/>
            <instruction instr-id='163' subinstr-id='16'/>
            <instruction instr-id='163' subinstr-id='18'/>
            <instruction instr-id='163' subinstr-id='20'/>
            <instruction instr-id='163' subinstr-id='22'/>
            <instruction instr-id='163' subinstr-id='24'/>
            <instruction instr-id='163' subinstr-id='26'/>
            <instruction instr-id='168' subinstr-id='0'/>
            <instruction instr-id='168' subinstr-id='2'/>
            <instruction instr-id='172' subinstr-id='-1'/>
            <instruction instr-id='181' subinstr-id='0'/>
            <instruction instr-id='181' subinstr-id='2'/>
            <instruction instr-id='181' subinstr-id='4'/>
            <instruction instr-id='181' subinstr-id='6'/>
            <instruction instr-id='181' subinstr-id='8'/>
            <instruction instr-id='181' subinstr-id='10'/>
         </cell>
         <cell id='1' start-row='2' start-col='3' >
            <bounding-box x1='486' y1='433' x2='656' y2='455'/>
            <content>• Cronbach’s alpha for summary scores
• Item-total correlations</content>
            <instruction instr-id='185' subinstr-id='-1'/>
            <instruction instr-id='194' subinstr-id='0'/>
            <instruction instr-id='194' subinstr-id='2'/>
            <instruction instr-id='194' subinstr-id='4'/>
            <instruction instr-id='194' subinstr-id='6'/>
            <instruction instr-id='194' subinstr-id='8'/>
            <instruction instr-id='194' subinstr-id='10'/>
            <instruction instr-id='194' subinstr-id='12'/>
            <instruction instr-id='194' subinstr-id='14'/>
            <instruction instr-id='194' subinstr-id='16'/>
            <instruction instr-id='194' subinstr-id='18'/>
            <instruction instr-id='194' subinstr-id='20'/>
            <instruction instr-id='194' subinstr-id='22'/>
            <instruction instr-id='194' subinstr-id='24'/>
            <instruction instr-id='194' subinstr-id='26'/>
            <instruction instr-id='194' subinstr-id='28'/>
            <instruction instr-id='198' subinstr-id='-1'/>
            <instruction instr-id='207' subinstr-id='0'/>
            <instruction instr-id='207' subinstr-id='2'/>
         </cell>
         <cell id='1' start-row='3' start-col='2' >
            <bounding-box x1='293' y1='363' x2='469' y2='396'/>
            <content>Agreement among responses when the PRO
is administered by two or more different
interviewers</content>
            <instruction instr-id='250' subinstr-id='0'/>
            <instruction instr-id='250' subinstr-id='2'/>
            <instruction instr-id='250' subinstr-id='4'/>
            <instruction instr-id='250' subinstr-id='6'/>
            <instruction instr-id='250' subinstr-id='8'/>
            <instruction instr-id='250' subinstr-id='10'/>
            <instruction instr-id='250' subinstr-id='12'/>
            <instruction instr-id='250' subinstr-id='16'/>
            <instruction instr-id='250' subinstr-id='18'/>
            <instruction instr-id='250' subinstr-id='20'/>
            <instruction instr-id='250' subinstr-id='22'/>
            <instruction instr-id='250' subinstr-id='24'/>
            <instruction instr-id='250' subinstr-id='26'/>
            <instruction instr-id='256' subinstr-id='0'/>
            <instruction instr-id='256' subinstr-id='2'/>
            <instruction instr-id='256' subinstr-id='4'/>
            <instruction instr-id='256' subinstr-id='6'/>
            <instruction instr-id='256' subinstr-id='8'/>
            <instruction instr-id='256' subinstr-id='10'/>
            <instruction instr-id='256' subinstr-id='12'/>
            <instruction instr-id='256' subinstr-id='14'/>
            <instruction instr-id='256' subinstr-id='16'/>
            <instruction instr-id='256' subinstr-id='18'/>
            <instruction instr-id='256' subinstr-id='20'/>
            <instruction instr-id='256' subinstr-id='22'/>
            <instruction instr-id='256' subinstr-id='24'/>
            <instruction instr-id='256' subinstr-id='26'/>
            <instruction instr-id='256' subinstr-id='28'/>
            <instruction instr-id='256' subinstr-id='30'/>
            <instruction instr-id='256' subinstr-id='32'/>
            <instruction instr-id='256' subinstr-id='34'/>
            <instruction instr-id='256' subinstr-id='36'/>
            <instruction instr-id='256' subinstr-id='38'/>
            <instruction instr-id='262' subinstr-id='0'/>
            <instruction instr-id='262' subinstr-id='2'/>
            <instruction instr-id='262' subinstr-id='4'/>
         </cell>
         <cell id='1' start-row='3' start-col='3' >
            <bounding-box x1='486' y1='385' x2='634' y2='395'/>
            <content>• Interclass correlation coefficient</content>
            <instruction instr-id='266' subinstr-id='-1'/>
            <instruction instr-id='274' subinstr-id='0'/>
            <instruction instr-id='274' subinstr-id='2'/>
            <instruction instr-id='274' subinstr-id='4'/>
         </cell>
         <cell id='1' start-row='4' start-col='2' >
            <bounding-box x1='293' y1='235' x2='475' y2='337'/>
            <content>Evidence that the instrument measures the
concept of interest including evidence from
qualitative studies that the items and domains
of an instrument are appropriate and
comprehensive relative to its intended
measurement concept, population, and use.
Testing other measurement properties will
not replace or rectify problems with content
validity.</content>
            <instruction instr-id='298' subinstr-id='16'/>
            <instruction instr-id='298' subinstr-id='18'/>
            <instruction instr-id='298' subinstr-id='20'/>
            <instruction instr-id='298' subinstr-id='22'/>
            <instruction instr-id='298' subinstr-id='24'/>
            <instruction instr-id='298' subinstr-id='26'/>
            <instruction instr-id='302' subinstr-id='0'/>
            <instruction instr-id='302' subinstr-id='2'/>
            <instruction instr-id='302' subinstr-id='4'/>
            <instruction instr-id='302' subinstr-id='6'/>
            <instruction instr-id='302' subinstr-id='8'/>
            <instruction instr-id='306' subinstr-id='0'/>
            <instruction instr-id='306' subinstr-id='2'/>
            <instruction instr-id='306' subinstr-id='4'/>
            <instruction instr-id='306' subinstr-id='6'/>
            <instruction instr-id='306' subinstr-id='8'/>
            <instruction instr-id='306' subinstr-id='10'/>
            <instruction instr-id='306' subinstr-id='14'/>
            <instruction instr-id='306' subinstr-id='16'/>
            <instruction instr-id='306' subinstr-id='18'/>
            <instruction instr-id='306' subinstr-id='20'/>
            <instruction instr-id='306' subinstr-id='22'/>
            <instruction instr-id='306' subinstr-id='24'/>
            <instruction instr-id='306' subinstr-id='26'/>
            <instruction instr-id='306' subinstr-id='28'/>
            <instruction instr-id='306' subinstr-id='30'/>
            <instruction instr-id='306' subinstr-id='32'/>
            <instruction instr-id='306' subinstr-id='34'/>
            <instruction instr-id='312' subinstr-id='0'/>
            <instruction instr-id='312' subinstr-id='2'/>
            <instruction instr-id='312' subinstr-id='4'/>
            <instruction instr-id='312' subinstr-id='6'/>
            <instruction instr-id='312' subinstr-id='8'/>
            <instruction instr-id='312' subinstr-id='10'/>
            <instruction instr-id='312' subinstr-id='12'/>
            <instruction instr-id='312' subinstr-id='14'/>
            <instruction instr-id='312' subinstr-id='16'/>
            <instruction instr-id='312' subinstr-id='18'/>
            <instruction instr-id='312' subinstr-id='20'/>
            <instruction instr-id='312' subinstr-id='22'/>
            <instruction instr-id='312' subinstr-id='24'/>
            <instruction instr-id='312' subinstr-id='26'/>
            <instruction instr-id='312' subinstr-id='28'/>
            <instruction instr-id='317' subinstr-id='0'/>
            <instruction instr-id='317' subinstr-id='2'/>
            <instruction instr-id='317' subinstr-id='4'/>
            <instruction instr-id='317' subinstr-id='6'/>
            <instruction instr-id='317' subinstr-id='8'/>
            <instruction instr-id='323' subinstr-id='0'/>
            <instruction instr-id='323' subinstr-id='2'/>
            <instruction instr-id='323' subinstr-id='4'/>
            <instruction instr-id='323' subinstr-id='6'/>
            <instruction instr-id='323' subinstr-id='8'/>
            <instruction instr-id='323' subinstr-id='10'/>
            <instruction instr-id='323' subinstr-id='12'/>
            <instruction instr-id='323' subinstr-id='14'/>
            <instruction instr-id='323' subinstr-id='16'/>
            <instruction instr-id='323' subinstr-id='18'/>
            <instruction instr-id='323' subinstr-id='20'/>
            <instruction instr-id='323' subinstr-id='22'/>
            <instruction instr-id='329' subinstr-id='0'/>
            <instruction instr-id='329' subinstr-id='2'/>
            <instruction instr-id='329' subinstr-id='4'/>
            <instruction instr-id='329' subinstr-id='6'/>
            <instruction instr-id='329' subinstr-id='8'/>
            <instruction instr-id='329' subinstr-id='10'/>
            <instruction instr-id='329' subinstr-id='12'/>
            <instruction instr-id='329' subinstr-id='14'/>
            <instruction instr-id='329' subinstr-id='16'/>
            <instruction instr-id='329' subinstr-id='18'/>
            <instruction instr-id='329' subinstr-id='20'/>
            <instruction instr-id='329' subinstr-id='22'/>
            <instruction instr-id='329' subinstr-id='24'/>
            <instruction instr-id='329' subinstr-id='26'/>
            <instruction instr-id='329' subinstr-id='28'/>
            <instruction instr-id='329' subinstr-id='30'/>
            <instruction instr-id='329' subinstr-id='32'/>
            <instruction instr-id='329' subinstr-id='34'/>
            <instruction instr-id='329' subinstr-id='36'/>
            <instruction instr-id='334' subinstr-id='0'/>
            <instruction instr-id='334' subinstr-id='2'/>
            <instruction instr-id='334' subinstr-id='4'/>
            <instruction instr-id='334' subinstr-id='6'/>
            <instruction instr-id='334' subinstr-id='8'/>
            <instruction instr-id='334' subinstr-id='10'/>
            <instruction instr-id='334' subinstr-id='12'/>
            <instruction instr-id='334' subinstr-id='14'/>
            <instruction instr-id='334' subinstr-id='16'/>
            <instruction instr-id='334' subinstr-id='18'/>
            <instruction instr-id='334' subinstr-id='20'/>
            <instruction instr-id='340' subinstr-id='0'/>
            <instruction instr-id='340' subinstr-id='2'/>
            <instruction instr-id='340' subinstr-id='4'/>
            <instruction instr-id='340' subinstr-id='6'/>
            <instruction instr-id='340' subinstr-id='8'/>
            <instruction instr-id='346' subinstr-id='0'/>
            <instruction instr-id='346' subinstr-id='2'/>
            <instruction instr-id='346' subinstr-id='4'/>
         </cell>
         <cell id='1' start-row='4' start-col='3' >
            <bounding-box x1='486' y1='253' x2='704' y2='336'/>
            <content>• Derivation of all items
• Qualitative interview schedule
• Interview or focus group transcripts
• Items derived from the transcripts
• Composition of patients used to develop content
• Cognitive interview transcripts to evaluate patient
understanding</content>
            <instruction instr-id='350' subinstr-id='-1'/>
            <instruction instr-id='359' subinstr-id='0'/>
            <instruction instr-id='359' subinstr-id='2'/>
            <instruction instr-id='359' subinstr-id='4'/>
            <instruction instr-id='359' subinstr-id='6'/>
            <instruction instr-id='359' subinstr-id='8'/>
            <instruction instr-id='359' subinstr-id='10'/>
            <instruction instr-id='359' subinstr-id='12'/>
            <instruction instr-id='363' subinstr-id='-1'/>
            <instruction instr-id='372' subinstr-id='0'/>
            <instruction instr-id='372' subinstr-id='2'/>
            <instruction instr-id='372' subinstr-id='4'/>
            <instruction instr-id='372' subinstr-id='6'/>
            <instruction instr-id='372' subinstr-id='8'/>
            <instruction instr-id='372' subinstr-id='10'/>
            <instruction instr-id='372' subinstr-id='12'/>
            <instruction instr-id='372' subinstr-id='14'/>
            <instruction instr-id='372' subinstr-id='16'/>
            <instruction instr-id='376' subinstr-id='-1'/>
            <instruction instr-id='385' subinstr-id='0'/>
            <instruction instr-id='385' subinstr-id='2'/>
            <instruction instr-id='385' subinstr-id='4'/>
            <instruction instr-id='385' subinstr-id='6'/>
            <instruction instr-id='385' subinstr-id='8'/>
            <instruction instr-id='385' subinstr-id='10'/>
            <instruction instr-id='385' subinstr-id='12'/>
            <instruction instr-id='385' subinstr-id='14'/>
            <instruction instr-id='385' subinstr-id='16'/>
            <instruction instr-id='385' subinstr-id='18'/>
            <instruction instr-id='385' subinstr-id='20'/>
            <instruction instr-id='385' subinstr-id='22'/>
            <instruction instr-id='385' subinstr-id='24'/>
            <instruction instr-id='385' subinstr-id='26'/>
            <instruction instr-id='385' subinstr-id='28'/>
            <instruction instr-id='385' subinstr-id='30'/>
            <instruction instr-id='389' subinstr-id='-1'/>
            <instruction instr-id='398' subinstr-id='0'/>
            <instruction instr-id='398' subinstr-id='2'/>
            <instruction instr-id='398' subinstr-id='4'/>
            <instruction instr-id='398' subinstr-id='6'/>
            <instruction instr-id='398' subinstr-id='8'/>
            <instruction instr-id='398' subinstr-id='10'/>
            <instruction instr-id='398' subinstr-id='12'/>
            <instruction instr-id='398' subinstr-id='14'/>
            <instruction instr-id='398' subinstr-id='16'/>
            <instruction instr-id='398' subinstr-id='18'/>
            <instruction instr-id='398' subinstr-id='20'/>
            <instruction instr-id='398' subinstr-id='22'/>
            <instruction instr-id='398' subinstr-id='24'/>
            <instruction instr-id='398' subinstr-id='26'/>
            <instruction instr-id='398' subinstr-id='28'/>
            <instruction instr-id='398' subinstr-id='30'/>
            <instruction instr-id='402' subinstr-id='-1'/>
            <instruction instr-id='411' subinstr-id='0'/>
            <instruction instr-id='411' subinstr-id='2'/>
            <instruction instr-id='411' subinstr-id='4'/>
            <instruction instr-id='411' subinstr-id='6'/>
            <instruction instr-id='411' subinstr-id='8'/>
            <instruction instr-id='411' subinstr-id='10'/>
            <instruction instr-id='411' subinstr-id='12'/>
            <instruction instr-id='411' subinstr-id='14'/>
            <instruction instr-id='411' subinstr-id='16'/>
            <instruction instr-id='411' subinstr-id='18'/>
            <instruction instr-id='411' subinstr-id='20'/>
            <instruction instr-id='411' subinstr-id='22'/>
            <instruction instr-id='411' subinstr-id='24'/>
            <instruction instr-id='411' subinstr-id='26'/>
            <instruction instr-id='411' subinstr-id='28'/>
            <instruction instr-id='411' subinstr-id='30'/>
            <instruction instr-id='411' subinstr-id='32'/>
            <instruction instr-id='411' subinstr-id='36'/>
            <instruction instr-id='411' subinstr-id='38'/>
            <instruction instr-id='411' subinstr-id='40'/>
            <instruction instr-id='411' subinstr-id='42'/>
            <instruction instr-id='411' subinstr-id='44'/>
            <instruction instr-id='411' subinstr-id='46'/>
            <instruction instr-id='411' subinstr-id='48'/>
            <instruction instr-id='411' subinstr-id='50'/>
            <instruction instr-id='411' subinstr-id='52'/>
            <instruction instr-id='415' subinstr-id='-1'/>
            <instruction instr-id='424' subinstr-id='0'/>
            <instruction instr-id='424' subinstr-id='2'/>
            <instruction instr-id='424' subinstr-id='4'/>
            <instruction instr-id='424' subinstr-id='6'/>
            <instruction instr-id='424' subinstr-id='8'/>
            <instruction instr-id='424' subinstr-id='10'/>
            <instruction instr-id='424' subinstr-id='12'/>
            <instruction instr-id='424' subinstr-id='14'/>
            <instruction instr-id='424' subinstr-id='16'/>
            <instruction instr-id='424' subinstr-id='18'/>
            <instruction instr-id='424' subinstr-id='20'/>
            <instruction instr-id='424' subinstr-id='22'/>
            <instruction instr-id='424' subinstr-id='24'/>
            <instruction instr-id='424' subinstr-id='26'/>
            <instruction instr-id='424' subinstr-id='28'/>
            <instruction instr-id='424' subinstr-id='30'/>
            <instruction instr-id='424' subinstr-id='32'/>
            <instruction instr-id='430' subinstr-id='0'/>
            <instruction instr-id='430' subinstr-id='2'/>
            <instruction instr-id='430' subinstr-id='4'/>
            <instruction instr-id='430' subinstr-id='6'/>
            <instruction instr-id='430' subinstr-id='8'/>
            <instruction instr-id='430' subinstr-id='10'/>
            <instruction instr-id='430' subinstr-id='12'/>
         </cell>
         <cell id='1' start-row='5' start-col='2' >
            <bounding-box x1='293' y1='165' x2='468' y2='233'/>
            <content>Evidence that relationships among items,
domains, and concepts conform to a priori
hypotheses concerning logical relationships
that should exist with measures of related
concepts or scores produced in similar or
diverse patient groups</content>
            <instruction instr-id='470' subinstr-id='0'/>
            <instruction instr-id='470' subinstr-id='2'/>
            <instruction instr-id='470' subinstr-id='4'/>
            <instruction instr-id='470' subinstr-id='6'/>
            <instruction instr-id='470' subinstr-id='8'/>
            <instruction instr-id='470' subinstr-id='10'/>
            <instruction instr-id='470' subinstr-id='12'/>
            <instruction instr-id='470' subinstr-id='14'/>
            <instruction instr-id='470' subinstr-id='16'/>
            <instruction instr-id='470' subinstr-id='18'/>
            <instruction instr-id='470' subinstr-id='20'/>
            <instruction instr-id='470' subinstr-id='22'/>
            <instruction instr-id='470' subinstr-id='24'/>
            <instruction instr-id='470' subinstr-id='26'/>
            <instruction instr-id='470' subinstr-id='28'/>
            <instruction instr-id='470' subinstr-id='30'/>
            <instruction instr-id='470' subinstr-id='32'/>
            <instruction instr-id='470' subinstr-id='34'/>
            <instruction instr-id='470' subinstr-id='36'/>
            <instruction instr-id='470' subinstr-id='38'/>
            <instruction instr-id='470' subinstr-id='40'/>
            <instruction instr-id='470' subinstr-id='42'/>
            <instruction instr-id='476' subinstr-id='0'/>
            <instruction instr-id='476' subinstr-id='2'/>
            <instruction instr-id='476' subinstr-id='4'/>
            <instruction instr-id='476' subinstr-id='6'/>
            <instruction instr-id='476' subinstr-id='8'/>
            <instruction instr-id='476' subinstr-id='10'/>
            <instruction instr-id='476' subinstr-id='12'/>
            <instruction instr-id='476' subinstr-id='14'/>
            <instruction instr-id='476' subinstr-id='16'/>
            <instruction instr-id='476' subinstr-id='18'/>
            <instruction instr-id='476' subinstr-id='20'/>
            <instruction instr-id='476' subinstr-id='22'/>
            <instruction instr-id='476' subinstr-id='24'/>
            <instruction instr-id='476' subinstr-id='26'/>
            <instruction instr-id='476' subinstr-id='28'/>
            <instruction instr-id='476' subinstr-id='32'/>
            <instruction instr-id='476' subinstr-id='34'/>
            <instruction instr-id='481' subinstr-id='0'/>
            <instruction instr-id='481' subinstr-id='2'/>
            <instruction instr-id='481' subinstr-id='4'/>
            <instruction instr-id='490' subinstr-id='0'/>
            <instruction instr-id='490' subinstr-id='2'/>
            <instruction instr-id='490' subinstr-id='4'/>
            <instruction instr-id='490' subinstr-id='6'/>
            <instruction instr-id='490' subinstr-id='8'/>
            <instruction instr-id='490' subinstr-id='10'/>
            <instruction instr-id='490' subinstr-id='12'/>
            <instruction instr-id='490' subinstr-id='14'/>
            <instruction instr-id='490' subinstr-id='16'/>
            <instruction instr-id='490' subinstr-id='18'/>
            <instruction instr-id='490' subinstr-id='20'/>
            <instruction instr-id='490' subinstr-id='22'/>
            <instruction instr-id='490' subinstr-id='24'/>
            <instruction instr-id='490' subinstr-id='26'/>
            <instruction instr-id='490' subinstr-id='28'/>
            <instruction instr-id='490' subinstr-id='30'/>
            <instruction instr-id='490' subinstr-id='32'/>
            <instruction instr-id='490' subinstr-id='34'/>
            <instruction instr-id='490' subinstr-id='36'/>
            <instruction instr-id='490' subinstr-id='38'/>
            <instruction instr-id='490' subinstr-id='40'/>
            <instruction instr-id='495' subinstr-id='0'/>
            <instruction instr-id='495' subinstr-id='2'/>
            <instruction instr-id='495' subinstr-id='4'/>
            <instruction instr-id='495' subinstr-id='6'/>
            <instruction instr-id='495' subinstr-id='8'/>
            <instruction instr-id='495' subinstr-id='10'/>
            <instruction instr-id='495' subinstr-id='12'/>
            <instruction instr-id='495' subinstr-id='14'/>
            <instruction instr-id='495' subinstr-id='16'/>
            <instruction instr-id='495' subinstr-id='18'/>
            <instruction instr-id='495' subinstr-id='20'/>
            <instruction instr-id='495' subinstr-id='22'/>
            <instruction instr-id='501' subinstr-id='0'/>
            <instruction instr-id='501' subinstr-id='2'/>
            <instruction instr-id='501' subinstr-id='4'/>
            <instruction instr-id='501' subinstr-id='6'/>
            <instruction instr-id='501' subinstr-id='10'/>
            <instruction instr-id='501' subinstr-id='12'/>
            <instruction instr-id='501' subinstr-id='14'/>
            <instruction instr-id='501' subinstr-id='16'/>
            <instruction instr-id='501' subinstr-id='18'/>
            <instruction instr-id='501' subinstr-id='20'/>
            <instruction instr-id='501' subinstr-id='22'/>
            <instruction instr-id='501' subinstr-id='24'/>
            <instruction instr-id='501' subinstr-id='28'/>
            <instruction instr-id='501' subinstr-id='30'/>
            <instruction instr-id='501' subinstr-id='32'/>
            <instruction instr-id='501' subinstr-id='34'/>
            <instruction instr-id='501' subinstr-id='36'/>
            <instruction instr-id='501' subinstr-id='38'/>
            <instruction instr-id='501' subinstr-id='40'/>
            <instruction instr-id='501' subinstr-id='42'/>
            <instruction instr-id='507' subinstr-id='0'/>
            <instruction instr-id='507' subinstr-id='2'/>
            <instruction instr-id='507' subinstr-id='4'/>
            <instruction instr-id='507' subinstr-id='6'/>
            <instruction instr-id='507' subinstr-id='8'/>
            <instruction instr-id='507' subinstr-id='10'/>
            <instruction instr-id='507' subinstr-id='12'/>
            <instruction instr-id='507' subinstr-id='14'/>
            <instruction instr-id='507' subinstr-id='16'/>
         </cell>
         <cell id='1' start-row='5' start-col='3' >
            <bounding-box x1='486' y1='175' x2='715' y2='232'/>
            <content>• Strength of correlation testing a priori hypotheses
(discriminant and convergent validity)
• Degree to which the PRO instrument can distinguish
among groups hypothesized a priori to be different
(known groups validity)</content>
            <instruction instr-id='511' subinstr-id='-1'/>
            <instruction instr-id='520' subinstr-id='0'/>
            <instruction instr-id='520' subinstr-id='2'/>
            <instruction instr-id='520' subinstr-id='4'/>
            <instruction instr-id='520' subinstr-id='6'/>
            <instruction instr-id='520' subinstr-id='8'/>
            <instruction instr-id='525' subinstr-id='0'/>
            <instruction instr-id='525' subinstr-id='2'/>
            <instruction instr-id='525' subinstr-id='4'/>
            <instruction instr-id='529' subinstr-id='0'/>
            <instruction instr-id='529' subinstr-id='2'/>
            <instruction instr-id='529' subinstr-id='4'/>
            <instruction instr-id='533' subinstr-id='0'/>
            <instruction instr-id='533' subinstr-id='2'/>
            <instruction instr-id='533' subinstr-id='4'/>
            <instruction instr-id='533' subinstr-id='6'/>
            <instruction instr-id='533' subinstr-id='8'/>
            <instruction instr-id='533' subinstr-id='10'/>
            <instruction instr-id='533' subinstr-id='12'/>
            <instruction instr-id='533' subinstr-id='14'/>
            <instruction instr-id='533' subinstr-id='16'/>
            <instruction instr-id='533' subinstr-id='18'/>
            <instruction instr-id='533' subinstr-id='20'/>
            <instruction instr-id='533' subinstr-id='22'/>
            <instruction instr-id='533' subinstr-id='24'/>
            <instruction instr-id='537' subinstr-id='-1'/>
            <instruction instr-id='546' subinstr-id='0'/>
            <instruction instr-id='546' subinstr-id='2'/>
            <instruction instr-id='546' subinstr-id='4'/>
            <instruction instr-id='546' subinstr-id='6'/>
            <instruction instr-id='546' subinstr-id='10'/>
            <instruction instr-id='546' subinstr-id='12'/>
            <instruction instr-id='546' subinstr-id='14'/>
            <instruction instr-id='546' subinstr-id='16'/>
            <instruction instr-id='546' subinstr-id='18'/>
            <instruction instr-id='546' subinstr-id='20'/>
            <instruction instr-id='546' subinstr-id='22'/>
            <instruction instr-id='546' subinstr-id='24'/>
            <instruction instr-id='546' subinstr-id='26'/>
            <instruction instr-id='546' subinstr-id='28'/>
            <instruction instr-id='546' subinstr-id='30'/>
            <instruction instr-id='546' subinstr-id='32'/>
            <instruction instr-id='546' subinstr-id='34'/>
            <instruction instr-id='546' subinstr-id='36'/>
            <instruction instr-id='546' subinstr-id='38'/>
            <instruction instr-id='546' subinstr-id='40'/>
            <instruction instr-id='546' subinstr-id='42'/>
            <instruction instr-id='546' subinstr-id='44'/>
            <instruction instr-id='546' subinstr-id='46'/>
            <instruction instr-id='546' subinstr-id='48'/>
            <instruction instr-id='551' subinstr-id='0'/>
            <instruction instr-id='551' subinstr-id='2'/>
            <instruction instr-id='551' subinstr-id='4'/>
            <instruction instr-id='551' subinstr-id='6'/>
            <instruction instr-id='551' subinstr-id='8'/>
            <instruction instr-id='551' subinstr-id='10'/>
            <instruction instr-id='551' subinstr-id='12'/>
            <instruction instr-id='551' subinstr-id='14'/>
            <instruction instr-id='551' subinstr-id='16'/>
            <instruction instr-id='551' subinstr-id='18'/>
            <instruction instr-id='551' subinstr-id='20'/>
            <instruction instr-id='551' subinstr-id='22'/>
            <instruction instr-id='551' subinstr-id='24'/>
            <instruction instr-id='556' subinstr-id='0'/>
            <instruction instr-id='556' subinstr-id='2'/>
            <instruction instr-id='556' subinstr-id='4'/>
            <instruction instr-id='556' subinstr-id='6'/>
            <instruction instr-id='556' subinstr-id='8'/>
            <instruction instr-id='561' subinstr-id='2'/>
            <instruction instr-id='561' subinstr-id='4'/>
            <instruction instr-id='561' subinstr-id='6'/>
            <instruction instr-id='561' subinstr-id='8'/>
            <instruction instr-id='561' subinstr-id='10'/>
            <instruction instr-id='565' subinstr-id='0'/>
            <instruction instr-id='565' subinstr-id='2'/>
            <instruction instr-id='565' subinstr-id='4'/>
            <instruction instr-id='565' subinstr-id='6'/>
            <instruction instr-id='565' subinstr-id='8'/>
            <instruction instr-id='565' subinstr-id='10'/>
            <instruction instr-id='565' subinstr-id='12'/>
            <instruction instr-id='565' subinstr-id='14'/>
            <instruction instr-id='565' subinstr-id='18'/>
            <instruction instr-id='565' subinstr-id='20'/>
            <instruction instr-id='565' subinstr-id='22'/>
            <instruction instr-id='565' subinstr-id='24'/>
            <instruction instr-id='565' subinstr-id='26'/>
            <instruction instr-id='565' subinstr-id='28'/>
            <instruction instr-id='565' subinstr-id='30'/>
         </cell>
         <cell id='1' start-row='6' start-col='2' >
            <bounding-box x1='293' y1='107' x2='473' y2='163'/>
            <content>Evidence that a PRO instrument can identify
differences in scores over time in individuals
or groups (similar to those in the clinical
trials) who have changed with respect to the
measurement concept</content>
            <instruction instr-id='600' subinstr-id='2'/>
            <instruction instr-id='600' subinstr-id='4'/>
            <instruction instr-id='600' subinstr-id='6'/>
            <instruction instr-id='600' subinstr-id='8'/>
            <instruction instr-id='600' subinstr-id='10'/>
            <instruction instr-id='600' subinstr-id='12'/>
            <instruction instr-id='600' subinstr-id='14'/>
            <instruction instr-id='600' subinstr-id='16'/>
            <instruction instr-id='600' subinstr-id='18'/>
            <instruction instr-id='600' subinstr-id='20'/>
            <instruction instr-id='604' subinstr-id='0'/>
            <instruction instr-id='604' subinstr-id='2'/>
            <instruction instr-id='604' subinstr-id='4'/>
            <instruction instr-id='604' subinstr-id='6'/>
            <instruction instr-id='604' subinstr-id='8'/>
            <instruction instr-id='604' subinstr-id='10'/>
            <instruction instr-id='604' subinstr-id='12'/>
            <instruction instr-id='604' subinstr-id='14'/>
            <instruction instr-id='608' subinstr-id='0'/>
            <instruction instr-id='608' subinstr-id='2'/>
            <instruction instr-id='608' subinstr-id='4'/>
            <instruction instr-id='608' subinstr-id='6'/>
            <instruction instr-id='608' subinstr-id='8'/>
            <instruction instr-id='608' subinstr-id='10'/>
            <instruction instr-id='608' subinstr-id='12'/>
            <instruction instr-id='612' subinstr-id='0'/>
            <instruction instr-id='612' subinstr-id='2'/>
            <instruction instr-id='612' subinstr-id='4'/>
            <instruction instr-id='612' subinstr-id='6'/>
            <instruction instr-id='612' subinstr-id='8'/>
            <instruction instr-id='612' subinstr-id='10'/>
            <instruction instr-id='612' subinstr-id='12'/>
            <instruction instr-id='612' subinstr-id='14'/>
            <instruction instr-id='612' subinstr-id='16'/>
            <instruction instr-id='612' subinstr-id='18'/>
            <instruction instr-id='612' subinstr-id='20'/>
            <instruction instr-id='612' subinstr-id='22'/>
            <instruction instr-id='612' subinstr-id='24'/>
            <instruction instr-id='612' subinstr-id='26'/>
            <instruction instr-id='612' subinstr-id='28'/>
            <instruction instr-id='617' subinstr-id='0'/>
            <instruction instr-id='617' subinstr-id='4'/>
            <instruction instr-id='617' subinstr-id='6'/>
            <instruction instr-id='617' subinstr-id='8'/>
            <instruction instr-id='617' subinstr-id='10'/>
            <instruction instr-id='617' subinstr-id='12'/>
            <instruction instr-id='617' subinstr-id='14'/>
            <instruction instr-id='617' subinstr-id='18'/>
            <instruction instr-id='617' subinstr-id='20'/>
            <instruction instr-id='617' subinstr-id='22'/>
            <instruction instr-id='617' subinstr-id='24'/>
            <instruction instr-id='617' subinstr-id='26'/>
            <instruction instr-id='622' subinstr-id='0'/>
            <instruction instr-id='622' subinstr-id='2'/>
            <instruction instr-id='622' subinstr-id='4'/>
            <instruction instr-id='622' subinstr-id='6'/>
         </cell>
         <cell id='1' start-row='6' start-col='3' >
            <bounding-box x1='486' y1='140' x2='633' y2='163'/>
            <content>• Within person change over time
• Effect size statistic</content>
            <instruction instr-id='626' subinstr-id='-1'/>
            <instruction instr-id='635' subinstr-id='0'/>
            <instruction instr-id='635' subinstr-id='2'/>
            <instruction instr-id='635' subinstr-id='4'/>
            <instruction instr-id='635' subinstr-id='6'/>
            <instruction instr-id='635' subinstr-id='8'/>
            <instruction instr-id='635' subinstr-id='10'/>
            <instruction instr-id='635' subinstr-id='12'/>
            <instruction instr-id='639' subinstr-id='-1'/>
            <instruction instr-id='648' subinstr-id='0'/>
            <instruction instr-id='648' subinstr-id='2'/>
         </cell>
      </region>
   </table>
</document>
